Bioinformatics

Unit-I Introduction
Introduction to bioinformatics, objectives of bioinformatics, Basic chemistry of nucleic acids,
structure of DNA & RNA, Genes, structure of bacterial chromosome, cloning methodology, Data
maintenance and Integrity Tasks.
Unit-II Bioinformatics Databases & Image Processing
Types of databases, Nucleotide sequence databases, Protein sequence databases, Protein
structure databases, Normalization, Data cleaning and transformation, Protein folding, protein
function, proteinpurification and characterization, Introduction to Java clients, CORBA, Using
MYSQL, Feature Extraction.
Unit-III Sequence Alignment and database searching
Introduction to sequence analysis, Models for sequence analysis, Methods of optimal alignment,
Tools for sequence alignment, Dynamics Programming, Heuristic Methods, Multiple sequence
Alignment
Unit-IV Gene Finding and Expression
Cracking the Genome, Biological decoder ring, finding genes through mathematics & learning,
Genes prediction tools, Gene Mapping, Application of Mapping, Modes of Gene Expression
data, Mining the Gene Expression Data
Unit-V Proteomics & Problem solving in Bioinformatics
Proteome analysis, tools for proteome analysis, Genetic networks, Network properties and
analysis, complete pathway simulation: E-cell, Genomic analysis for DNA & Protein sequences ,
Strategies and options for similarity search , flowcharts for protein structure prediction .


List of References
1.Gopal & Jones, BIOINFORMATICS with fundamentals of Genomics & Proteomics ,TMH Pub
2.Rastogi , Bioinformatics –Concepts , skills & Applications , CBS Pub
3.Bergeron , Bioinformatics computing , PHI
4.Claverie , Bioinformatics , Wiley pub
5.Baxevanis , Bioinformatics , Wiley Pub
6.Stekel , Micrarray BioInformatics , Cambridge